Immunogenetics Center (UIC)
Pathology
About
The UCLA Immunogenetics Center (UIC) provides state-of-the-art Histocompatibility and Immunogenetics testing for solid organ and stem cell transplantation, pre- and post-transplant immune assessment and testing for diagnosis of diseases with associations to the Human Leukocyte Antigens (HLA). As one of the first established laboratories in Histocompatibility and Immunogenetics, we continue to advance the field through research, clinical innovation, proficiency testing and educational training. UIC provides customized testing and support services for clinical trials and clinical research to monitor response to experimental therapy.
The UIC is a nationally recognized reference laboratory for Histocompatibility and Immunogenetics testing and is licensed by the States of California, New York, Maryland, Pennsylvania and Rhode Island, and is CMS certified and accredited by the American Society for Histocompatibility and Immunogenetics (ASHI).
Leadership
Services
The UCLA Immunogenetics Center performs a diverse range of tests for Histocompatibility testing for solid organ and stem cell transplantation, autoimmune disease, and immunogenetics. Our laboratory performs an array of genotyping and serum screening tests that result at various levels of sensitivity and specificity.
Genotyping
HLA Typing
- Intermediate Resolution (RSSO)
- High Resolution: Long Range/Full Gene Next Generation Sequencing (NGS)
- Disease association and drug hypersensitivity
- MICA
- KIR
Chimerism and Engraftment Monitoring
Engraftment monitoring by testing of short tandem repeats (STR) enables determination of the level of donor cell engraftment in a recipient following transplantation. STR is an important tool that aids in the diagnosis of graft rejection and disease relapse. In order to identify informative alleles, a pre-transplant evaluation of the recipient and donor is required.
HLA and Non-HLA Antibody Testing and Crossmatching
HLA:
- Luminex Panel Reactive Antibody Screen
- HLA Single Antigen Bead Luminex Test
- HLA Single Antigen-C1q Screen
- Antibody Specificity Profile
- T and B cell Complement Dependent Cytotoxic Crossmatch
- T and B cell Flow Cytometric Crossmatch (with or without Pronase)
Non-HLA:
- MICA Single Antigen Antibody Screen
- AT1R ELISA
- Endothelial Cell Crossmatch
Virtual Crossmatch
- Donor specific HLA antibody assessment (DSA)
- Risk assessment
- Donor selection
Reference Programs
Since 1974, our Reference programs have provided reagents for quality control and standardization in the field of Histocompatibility and Immunogenetics. Our programs provide external proficiency testing services, reference DNA and cell samples, and educational challenges.