Cardiac Muscle Cell Core
Cardiovascular Research Theme
Overview
The UCLA Cardiovascular Research Theme will provide cardiac muscle cells as a core service at a highly subsidized rate. The goal of this service is to provide a readily available resource of cardiac muscle cells for investigators performing ex vivo experiments on cardiac muscle cells.
Leadership
Services
Two types of cardiac muscle cells will be provided.
- Neonatal rat ventricular cardiomyocytes (NRVM). These cells beat in the dish for 3-7 days and provide a platform for determining effects of toxins, drugs or other genetic manipulation of the cardiac muscle cell.
- Human embryonic stem cell or human iPSC derived cardiomyocytes. H9 or other NIH-approved lines and UCLA-approved lines are used as a source for the differentiation of cardiac muscle cells. Human pluripotent stem cell-derived cardiac muscle cells will be handed to investigators at their preferred time point of differentiation. To maintain consistency, standard differentiation programs are used. CRISPR/Cas edited hPSC-derived cardiomyocytes will be introduced as a core service in the recent future.