Mouse Integrative Genetics and Phenotyping Core
Comprehensive Liver Research Center
Overview
The Mouse Integrative Genetics and Phenotyping Core offers the use of mouse genetics and biospecimens, alongside the integration of mouse and human data to support discovery science into MASLD mechanisms. The core also provides experimental validation via mouse models of MASLD and offers phenotyping services in MASLD ‘humanized’ mouse models. Comprehensive histopathological assessments of mouse livers is available through collaboration with the TPCL Director Dr. Samuel French. The integration of human and mouse data will allow the Center members to conduct mechanistic studies, ultimately advancing our understanding of the MASLD spectrum.
By offering the unique database of 100+ genetically diverse inbred strains of mice, expertise, bioinformatical analyses, and consultation required for the seamless integration of human and mouse MASLD data, as well as the expertise to perform in vivo validation studies using various MASLD models, the core will provide accurate, time-efficient, and cost-effective phenotyping services to assess MASLD. This initiative is crucial for furthering the development of diagnostic and therapeutic approaches while embracing ‘precision hepatology.
Leadership
Services
- Access to 100+ genetically diverse inbred strains of mice showing differential effects on MASLD, MASH and fibrosis
- Consultations and expertise on bioinformatic analyses and seamless integration of human and mouse MASLD datasets
- Access to expertise in performing in vivo validation studies using various MASLD mouse models
- Comprehensive phenotyping services of liver including assessments of metabolic, histopathological and immunological markers of various stages of MASLD, MASH, fibrosis and HCC as well as measures of glucose intolerance and insulin resistance
- Detailed histopathological analyses of mouse liver through the core's collaboration with TPCL